Solid-phase synthesis of 2,3-dsubstituted benzo[b]thiophenes and benzo[b]selenophenes

被引：52

作者：

Bui, CT ^{[1
]}

Flynn, BL ^{[1
]}

机构：

[1] Care Of La Trobe Univ, Iliad Chem Pty Ltd, Dept Chem, Bundoora, Vic 3086, Australia

来源：

JOURNAL OF COMBINATORIAL CHEMISTRY | 2006年 / 8卷 / 02期

关键词：

D O I：

10.1021/cc050066w

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A concise and efficient solid-phase synthesis of benzo[b]thiophenes and benzo[b]selenophenes based on a combination of palladium-mediated coupling and iodocyclization protocols has been developed.

引用

页码：163 / 167

页数：5

共 28 条

[1]

[Anonymous], 1999, SULFUR REPORTS

[2] Synthesis, X-ray crystal structure and tubulin-binding properties of a benzofuran analogue of the potent cytotoxic agent combretastatin A4 [J].

Banwell, MG ;

Flynn, BL ;

Willis, AC ;

Hamel, E .

AUSTRALIAN JOURNAL OF CHEMISTRY, 1999, 52 (08) :767-774

[3] Convergent syntheses of the pyrrolic marine natural products lamellarin-O, lamellarin-Q, lukianol-A and some more highly oxygenated congeners [J].

Banwell, MG ;

Flynn, BL ;

Hamel, E ;

Hockless, DCR .

CHEMICAL COMMUNICATIONS, 1997, (02) :207-208

[4]

Bianchini C, 1997, SYNLETT, P643

[5] IMMUNOTOXICOLOGIC STUDIES WITH CI-959, A NOVEL BENZOTHIOPHENE CELL ACTIVATION INHIBITOR [J].

BLEAVINS, MR ;

DELAIGLESIA, FA ;

MCCAY, JA ;

WHITE, KL ;

MUNSON, AE .

TOXICOLOGY, 1995, 98 (1-3) :111-123

[6] 3-ALKOXYBENZO[B]THIOPHENE-2-CARBOXAMIDES AS INHIBITORS OF NEUTROPHIL-ENDOTHELIAL CELL-ADHESION [J].

BOSCHELLI, DH ;

KRAMER, JB ;

CONNOR, DT ;

LESCH, ME ;

SCHRIER, DJ ;

FERIN, MA ;

WRIGHT, CD .

JOURNAL OF MEDICINAL CHEMISTRY, 1994, 37 (06) :717-718

[7]

Bryant HU, 1998, P SOC EXP BIOL MED, V217, P45

[8] A benzothiophene-carboxamide is a potent inhibitor of IL-1 beta induced VCAM-1 gene expression in human endothelial cells [J].

Cobb, RR ;

Felts, KA ;

McKenzie, TC ;

Parry, GCN ;

Mackman, N .

FEBS LETTERS, 1996, 382 (03) :323-326

[9] One-pot synthesis of benzo[b]furan and indole inhibitors of tubulin polymerization [J].

Flynn, BL ;

Hamel, E ;

Jung, MK .

JOURNAL OF MEDICINAL CHEMISTRY, 2002, 45 (12) :2670-2673

[10] The synthesis and tubulin binding activity of thiophene-based analogues of combretastatin A-4 [J].

Flynn, BL ;

Flynn, GP ;

Hamel, E ;

Jung, MK .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2001, 11 (17) :2341-2343

← 1 2 3 →