A ring-closing olefin metathesis approach to bridged azabicyclic structures

被引：46

作者：

Neipp, CE ^{[1
]}

Martin, SF ^{[1
]}

机构：

[1] Univ Texas, Dept Chem & Biochem, Austin, TX 78712 USA

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 10期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0040-4039(02)00100-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A facile and general entry to functionalized bridged bicyclic nitrogen heterocycles has been developed that involves the ring-closing metathesis (RCM) of cis-2,6-dialkenyl-N-acyl piperidines that were readily prepared from glutarimide or 4-methoxypyridine. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

收藏

页码：1779 / 1782

页数：4

相关论文

共 52 条

[1]

[Anonymous], 1981, INTRO ALKALOIDS BIOG

[2] Formation of medium-size bridged ring systems via ring-closing metathesis of 2,5-disubstituted-2,3-dihydro-1H-pyrroles [J].

Bamford, SJ ;

Goubitz, K ;

van Lingen, HL ;

Luker, T ;

Schenk, H ;

Hiemstra, H .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 2000, (03) :345-351

[3] Anodic amide oxidation/olefin metathesis strategies: Developing a unified approach to the synthesis of bicyclic lactam peptidomimetics [J].

Beal, LM ;

Liu, B ;

Chu, WH ;

Moeller, KD .

TETRAHEDRON, 2000, 56 (52) :10113-10125

[4] A HIGHLY STEREOCONTROLLED, 4-STEP SYNTHESIS OF (+/-)-LASUBINE-II [J].

BROWN, JD ;

FOLEY, MA ;

COMINS, DL .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1988, 110 (22) :7445-7447

[5] A(1,3) INTERACTION AND CONFORMATIONAL ENERGY OF AXIAL-AXIAL 1,3-DIMETHYL INTERACTION [J].

CHOW, YL ;

COLON, CJ ;

TAM, JNS .

CANADIAN JOURNAL OF CHEMISTRY, 1968, 46 (17) :2821-&

[6] SYNTHESIS OF GAMMA-LACTAM ANALOGS OF 1-ACETOXY CARBAPENEM DERIVATIVES [J].

COULTON, S ;

FRANCOIS, I ;

SOUTHGATE, R .

TETRAHEDRON LETTERS, 1990, 31 (47) :6923-6926

[7] SYNTHESIS OF (+/-)-FERRUGININE AND (+/-)-ANHYDROECGONINE METHYL-ESTER BY A TANDEM CYCLOPROPANATION COPE REARRANGEMENT [J].

DAVIES, HML ;

SAIKALI, E ;

YOUNG, WB .

JOURNAL OF ORGANIC CHEMISTRY, 1991, 56 (19) :5696-5700

[8]

DESLONGCHAMPS P, 1983, STEREOELECTRONIC EFF, pCH6

[9] Ring closing metathesis reactions of isoquinoline and β-carboline enamines [J].

Evans, P ;

Grigg, R ;

York, M .

TETRAHEDRON LETTERS, 2000, 41 (20) :3967-3970

[10] Application of ring-closing metathesis to the formal total synthesis of (+)-FR900482 [J].

Fellows, IM ;

Kaelin, DE ;

Martin, SF .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2000, 122 (44) :10781-10787

← 1 2 3 4 5 6 →