Roles of NOTCH1 as a Therapeutic Target and a Biomarker for Lung Cancer: Controversies and Perspectives

被引：30

作者：

Guo, Lixia ^{[1
]}

Zhang, Ting ^{[1
]}

Xiong, Ying ^{[1
,2
]}

Yang, Yanan ^{[1
,3
,4
,5
]}

机构：

[1] Mayo Clin, Thorac Dis Res Unit, Div Pulm & Crit Care Med, Dept Internal Med,Coll Med, Rochester, MN 55905 USA

[2] Univ Penn, Sch Arts & Sci, Philadelphia, PA 19104 USA

[3] Mayo Clin, Coll Med, Dept Biochem & Mol Biol, Rochester, MN 55905 USA

[4] Mayo Clin, Ctr Canc, Dev Therapeut Program, Rochester, MN 55905 USA

[5] Mayo Clin, Ctr Canc, Cell Biol Program, Rochester, MN 55905 USA

来源：

DISEASE MARKERS | 2015年 / 2015卷

关键词：

GROWTH-FACTOR RECEPTOR; STEM-CELLS; ADENOCARCINOMA; ACTIVATION; EXPRESSION; INVASION; OVEREXPRESSION; PROLIFERATION; PROGRESSION; METASTASIS;

D O I：

10.1155/2015/520590

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 [微生物学]; 090105 [作物生产系统与生态工程];

摘要：

Lung cancer is one of the most common types of human malignancies and the leading cause of cancer-related death. Patients with surgically resectable early stage lung cancer are more likely curable, but currently only a small population of patients can be diagnosed at such a stage, partly due to our incomplete understanding of the biology of lung cancer and the lack of diagnostic and prognostic biomarkers. Recent studies have shown that NOTCH1 is a critical regulator of human carcinogenesis and has been implicated in multiple steps of cancer development and progression. Herein, we review recent findings about the role of NOTCH1 in lung cancer and discuss its potential usefulness as both a therapeutic target and a biomarker for lung cancer.

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页数：8

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