Mapping of the metalloproteinase gene matrilysin (MMP7) to human chromosome 11q21->q22

被引：18

作者：

Knox, JD

Boreham, DR

Walker, JA

Morrison, DP

Matrisian, LM

Nagle, RB

Bowden, GT

机构：

[1] ATOM ENERGY CANADA LTD,CHALK RIVER,ON,CANADA

[2] VANDERBILT UNIV,DEPT CELL BIOL,NASHVILLE,TN

[3] UNIV ARIZONA,DEPT RADIAT ONCOL,TUCSON,AZ

来源：

CYTOGENETICS AND CELL GENETICS | 1996年 / 72卷 / 2-3期

关键词：

D O I：

10.1159/000134181

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The matrix metalloproteinase, matrilysin, is thought to play an important role in the early steps of tumor progression. We determined the chromosome location of the matrilysin gene (MMP7) by Southern and PCR analysis of two different panels of somatic cell hybrids and in situ hybridization of metaphase chromosomes. Matrilysin maps to the region, 11q21-->q22, adding MMP7 to the cluster of matrix metalloproteinase genes that have already mapped to this region.

引用

页码：179 / 182

页数：4

共 20 条

[1]

Alexander CM, 1991, CELL BIOL EXTRACELLU, P255

[2] THE ORDER AND ORIENTATION OF A CLUSTER OF METALLOPROTEINASE GENES, STROMELYSIN-2, COLLAGENASE, AND STROMELYSIN, TOGETHER WITH D11S385, ON CHROMOSOME-11Q22-Q23 [J].