Epigenetics, evolution, endocrine disruption, health, and disease

被引：211

作者：

Crews, David

McLachlan, John A.

机构：

[1] Univ Texas, Sect Integrat Biol, Austin, TX 78712 USA

[2] Tulane Univ, Environm Endocrinol Lab, Ctr Bioenvironm Res, New Orleans, LA 70112 USA

[3] Xavier Univ, New Orleans, LA 70112 USA

来源：

ENDOCRINOLOGY | 2006年 / 147卷 / 06期

关键词：

D O I：

10.1210/en.2005-1122

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

Endocrine-disrupting chemicals (EDCs) in the environment have been linked to human health and disease. This is particularly evident in compounds that mimic the effects of estrogens. Exposure to EDCs early in life can increase risk levels of compromised physical and mental health. Epigenetic mechanisms have been implicated in this process. Transgenerational consequences of EDC exposure is also discussed in both proximate (mechanism) and ultimate ( evolution) context as well as recent work suggesting how such transmission might become incorporated into the genome and subject to selection. We suggest a perspective for exploring and ultimately coming to understand diseases that may have environmental or endocrine origins.

引用

页码：S4 / S10

页数：7

共 81 条

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Uterine responsiveness to estradiol and DNA methylation are altered by fetal exposure to diethylstilbestrol and methoxychlor in CD-1 mice: Effects of low versus high doses [J].