Prenatal diethylstilbestrol (DES) exposure is associated with uterine leiomyoma development

被引:74
作者
Baird, DD
Newbold, R
机构
[1] NIEHS, Epidemiol Branch, NIH, Dept Hlth & Human Serv, Res Triangle Pk, NC 27709 USA
[2] NIEHS, Mol Toxicol Lab, NIH, Dept Hlth & Human Serv, Res Triangle Pk, NC 27709 USA
基金
美国国家卫生研究院;
关键词
diethylstilbestrol; prenatal exposure; uterine leiomyoma; uterine fibroids; epidemiology; environmental estrogens; endocrine disrupters;
D O I
10.1016/j.reprotox.2005.01.002
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Early life exposure to DES causes uterine leiomyomata in laboratory animals. We examined the relationship between prenatal DES exposure and development of uterine leiomyomata in women. Among randomly selected study participants (819 black women, 504 white women), leiomyoma status was determined by ultrasound screening (70%) or surgical record review (7%). We relied on self-report of prior diagnosis in 13%. Leiomyoma status could not be ascertained for 10% and they were excluded from analyses. Prenatal DES exposure was assessed by interview. All five of the black women who reported DES exposure had leiomyomata. Among white women, 76% who reported prenatal DES exposure had leiomyomata compared with 52% of the unexposed (adjusted odds ratio for whites: 2.4; 95% confidence interval CI: 1.1-5.4). Exposed women tended to have larger tumors. Results were robust to sensitivity analyses. Findings support experimental animal data and indicate a role for prenatal estrogen exposure in the etiology of human uterine leiomyoma. (c) 2005 Elsevier Inc. All rights reserved.
引用
收藏
页码:81 / 84
页数:4
相关论文
共 21 条
[1]   Invited commentary: Uterine leiomyomata - We know so little but could learn so much [J].
Baird, DD .
AMERICAN JOURNAL OF EPIDEMIOLOGY, 2004, 159 (02) :124-126
[2]   High cumulative incidence of uterine leiomyoma in black and white women: Ultrasound evidence [J].
Baird, DD ;
Dunson, DB ;
Hill, MC ;
Cousins, D ;
Schectman, JM .
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 2003, 188 (01) :100-107
[3]   ALTERATIONS IN DEVELOPING RAT UTERINE CELL-POPULATIONS AFTER NEONATAL EXPOSURE TO ESTROGENS AND ANTIESTROGENS [J].
BRANHAM, WS ;
ZEHR, DR ;
CHEN, JJ ;
SHEEHAN, DM .
TERATOLOGY, 1988, 38 (03) :271-279
[4]   HISTOLOGIC, MORPHOMETRIC, AND IMMUNOCYTOCHEMICAL ANALYSIS OF MYOMETRIAL DEVELOPMENT IN RATS AND MICE .2. EFFECTS OF DES ON DEVELOPMENT [J].
BRODY, JR ;
CUNHA, GR .
AMERICAN JOURNAL OF ANATOMY, 1989, 186 (01) :21-42
[5]  
DIECKMANN WJ, 1953, AM J OBSTET GYNECOL, V66, P1062
[6]   Hysterectomy rates in the United States 1990-1997 [J].
Farquhar, CM ;
Steiner, CA .
OBSTETRICS AND GYNECOLOGY, 2002, 99 (02) :229-234
[7]   DIETHYLSTILBESTROL REVISITED - A REVIEW OF THE LONG-TERM HEALTH-EFFECTS [J].
GIUSTI, RM ;
IWAMOTO, K ;
HATCH, EE .
ANNALS OF INTERNAL MEDICINE, 1995, 122 (10) :778-788
[8]   CLONAL DETERMINATION OF UTERINE LEIOMYOMAS BY ANALYZING DIFFERENTIAL INACTIVATION OF THE X-CHROMOSOME-LINKED PHOSPHOGLYCEROKINASE GENE [J].
HASHIMOTO, K ;
AZUMA, C ;
KAMURA, T ;
NOBUNAGA, T ;
KANAI, T ;
SAWADA, M ;
NOGUCHI, S ;
SAJI, F .
GYNECOLOGIC AND OBSTETRIC INVESTIGATION, 1995, 40 (03) :204-208
[9]  
HERBST AL, 1970, CANCER, V25, P745, DOI 10.1002/1097-0142(197004)25:4<745::AID-CNCR2820250402>3.0.CO
[10]  
2-2