HIV-1 Transmission during Early Antiretroviral Therapy: Evaluation of Two HIV-1 Transmission Events in the HPTN 052 Prevention Study

被引：21

作者：

Ping, Li-Hua ^{[1
]}

Jabara, Cassandra B. ^{[2
]}

Rodrigo, Allen G. ^{[3
]}

Hudelson, Sarah E. ^{[4
]}

Piwowar-Manning, Estelle ^{[4
]}

Wang, Lei ^{[5
]}

Eshleman, Susan H. ^{[4
]}

Cohen, Myron S. ^{[6
,7
]}

Swanstrom, Ronald ^{[7
,8
]}

机构：

[1] Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA

[2] Univ N Carolina, Dept Biol, Chapel Hill, NC 27599 USA

[3] Natl Evolutionary Synth Ctr, Durham, NC USA

[4] Johns Hopkins Univ, Sch Med, Dept Pathol, Baltimore, MD 21205 USA

[5] Fred Hutchinson Canc Res Ctr, Vaccine & Infect Dis Div, Seattle, WA 98104 USA

[6] Univ N Carolina, Div Infect Dis, Chapel Hill, NC USA

[7] Univ N Carolina, UNC Ctr AIDS Res, Chapel Hill, NC 27515 USA

[8] Univ N Carolina, Dept Biochem & Biophys, Chapel Hill, NC USA

来源：

PLOS ONE | 2013年 / 8卷 / 09期

基金：

美国国家卫生研究院;

关键词：

HETEROSEXUAL TRANSMISSION; INFECTION; INITIATION; COUPLES;

D O I：

10.1371/journal.pone.0071557

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In the HPTN 052 study, transmission between HIV-discordant couples was reduced by 96% when the HIV-infected partner received suppressive antiretroviral therapy (ART). We examined two transmission events where the newly infected partner was diagnosed after the HIV-infected partner (index) initiated therapy. We evaluated the sequence complexity of the viral populations and antibody reactivity in the newly infected partner to estimate the dates of transmission to the newly infected partners. In both cases, transmission most likely occurred significantly before HIV-1 diagnosis of the newly infected partner, and either just before the initiation of therapy or before viral replication was adequately suppressed by therapy of the index. This study further strengthens the conclusion about the efficacy of blocking transmission by treating the infected partner of discordant couples. However, this study does not rule out the potential for HIV-1 transmission to occur shortly after initiation of ART, and this should be recognized when antiretroviral therapy is used for HIV-1 prevention.

引用

页数：5

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