The allograft inflammatory factor-1 family of proteins

被引：112

作者：

Deininger, MH ^{[1
]}

Meyermann, R ^{[1
]}

Schluesener, HJ ^{[1
]}

机构：

[1] Univ Tubingen, Inst Brain Res, D-72076 Tubingen, Germany

来源：

FEBS LETTERS | 2002年 / 514卷 / 2-3期

关键词：

allograft inflammatory factor-1; ionized Ca2+-binding adapter molecule; interferon-responsive transcript-1;

D O I：

10.1016/S0014-5793(02)02430-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The allograft inflammatory factor-1 (AIF-1) is a 17 kDa interferon-gamma-inducible Ca2+-binding EF-hand protein that is encoded within the HLA class III genomic region. Three proteins are probably identical with AIF-1 termed Iba1 (ionized Ca2+- binding adapter), MRF-1 (microglia response factor) and daintain. Considerable but not complete sequence identity with AIF-1 has been described for IRT-1 (interferon-responsive transcript), BART-1 (balloon angioplasty-responsive transcript), and other, yet unassigned alternatively spliced variants. In this review, genomic and functional characteristics of AIF-1-related proteins are summarized and a common nomenclature is proposed. (C) 2002 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.

引用

页码：115 / 121

页数：7

共 51 条

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