Promoter methylation and inactivation of tumour-suppressor genes in oral squamous-cell carcinoma

被引：180

作者：

Ha, PK ^{[1
]}

Califano, JA ^{[1
]}

机构：

[1] Johns Hopkins Univ Hosp, Dept Otolaryngol Head & Neck Surg, Baltimore, MD 21287 USA

来源：

LANCET ONCOLOGY | 2006年 / 7卷 / 01期

关键词：

D O I：

10.1016/S1470-2045(05)70540-4

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Genetic alterations that lead to loss or changes in tumour-suppressor genes are known to contribute to oral carcinogenesis. Traditional molecular methods to detect such losses have relied on mutation analysis or deletion of the gene. However, epigenetic mechanisms could also contribute to silencing of turnour-suppressor genes. Methylation regions rich in CpG promoters prevent DNA transcription by changing the binding of histone complexes. The substantial contribution of methylation, specifically in oral squamous-cell carcinoma, is now being realised and investigated.

引用

页码：77 / 82

页数：6

共 55 条

[11] A GENOMIC SEQUENCING PROTOCOL THAT YIELDS A POSITIVE DISPLAY OF 5-METHYLCYTOSINE RESIDUES IN INDIVIDUAL DNA STRANDS [J].

FROMMER, M ;

MCDONALD, LE ;

MILLAR, DS ;

COLLIS, CM ;

WATT, F ;

GRIGG, GW ;

MOLLOY, PL ;

PAUL, CL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (05) :1827-1831

[12] Loss of heterozygosity at 9q33 and hypermethylation of the DBCCR1 gene in oral squamous cell carcinoma [J].

Gao, S ;

Worm, J ;

Guldberg, P ;

Eiberg, H ;

Krogdahl, A ;

Sorensen, JA ;

Liu, CJ ;

Reibel, J ;

Dabelsteen, E .

BRITISH JOURNAL OF CANCER, 2004, 91 (04) :760-764

[13] Intraoperative molecular margin analysis in head and neck cancer [J].

Goldenberg, D ;

Harden, S ;

Masayesva, BG ;

Ha, P ;

Benoit, N ;

Westra, WH ;

Koch, WM ;

Sidransky, D ;

Califano, JA .

ARCHIVES OF OTOLARYNGOLOGY-HEAD & NECK SURGERY, 2004, 130 (01) :39-44

[14]

Gonzalgo ML, 1997, CANCER RES, V57, P594

[15] Structure and methylation-based silencing of a gene (DBCCR1) within a candidate bladder cancer tumor suppressor region at 9q32-q33 [J].

Habuchi, T ;

Luscombe, N ;

Elder, PA ;

Knowles, MA .

GENOMICS, 1998, 48 (03) :277-288

[16] Patterns of gene promoter methylation in squamous cell cancer of the head and neck [J].

Hasegawa, M ;

Nelson, HH ;

Peters, E ;

Ringstrom, E ;

Posner, M ;

Kelsey, KT .

ONCOGENE, 2002, 21 (27) :4231-4236

[17]

HATADA I, 1993, NUCLEIC ACIDS RES, V21, P5577, DOI 10.1093/nar/21.24.5577

[18]

Herman JG, 1996, CANCER RES, V56, P722

[19] Methylation-specific PCR: A novel PCR assay for methylation status of CpG islands [J].

Herman, JG ;

Graff, JR ;

Myohanen, S ;

Nelkin, BD ;

Baylin, SB .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (18) :9821-9826

[20]

Huang THM, 1997, CANCER RES, V57, P1030

← 1 2 3 4 5 6 →