The UBQLN1 polymorphism, UBQ-8i, at 9q22 is not associated with Alzheimer's disease with onset before 70 years

被引：29

作者：

Brouwers, N

Sleegers, K

Engelborghs, S

Bogaerts, V

van Duijn, CM

De Deyn, PP

Van Broeckhoven, C

Dermaut, B

机构：

[1] Univ Antwerp Flanders Interuniv Inst Biotechnol, Dept Mol Genet, B-2610 Antwerp, Belgium

[2] Univ Antwerp, Inst Born Bunge, B-2610 Antwerp, Belgium

[3] Erasmus Med Ctr, Dept Epidemiol & Biostat, Rotterdam, Netherlands

[4] Univ Antwerp, Inst Born Bunge, Lab Neurochem & Behav, B-2020 Antwerp, Belgium

[5] Univ Antwerp, Middelheim Gen Hosp ZNA, Dept Neurol & Memory Clin, B-2020 Antwerp, Belgium

来源：

NEUROSCIENCE LETTERS | 2006年 / 392卷 / 1-2期

关键词：

Alzheimer's disease; ubiquilin; 1; chromosome; 9; genetic association study;

D O I：

10.1016/j.neulet.2005.08.064

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

An intronic polymorphism affecting alternative splicing of exon 8 of ubiquilin 1 (UBQLN1), that is located at a well established Alzheimer's disease (AD) locus on chromosome 9q22, was recently associated with increased risk for late-onset AD. We analyzed this polymorphism in two independent AD samples consisting of patients with an onset age 70 years or less, but did not observe statistically significant association. Our study does not support a major role for this UBQLN1 polymorphism in AD patients with an earlier onset of disease. (C) 2005 Elsevier Ireland Ltd. All rights reserved.

引用

页码：72 / 74

页数：3

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