PRNP Val129 homozygosity increases risk for early-onset Alzheimer's disease

被引：85

作者：

Dermaut, B

Croes, EA

Rademakers, R

Van den Broeck, M

Cruts, M

Hofman, A

van Duijn, CM

Van Broeckhoven, C

机构：

[1] Univ Instelling Antwerp VIB, Dept Mol Genet, B-2610 Antwerp, Belgium

[2] Erasmus Univ, Med Ctr, Dept Biostat & Epidemiol, Rotterdam, Netherlands

来源：

ANNALS OF NEUROLOGY | 2003年 / 53卷 / 03期

关键词：

D O I：

10.1002/ana.10507

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We analyzed the PRNP M129V polymorphism in a Dutch population-based early-onset Alzheimer's disease sample. We observed a significant association between early-onset Alzheimer's disease and homozygosity of M129V (odds ratio [OR], 1.9; 95% confidence interval [CI], 1.1-3.3; P = 0.02) with the highest risk for V homozygotes (OR, 3.2; 95% CI, 1.4-7.1; p < 0.01). In patients with a positive family history, these risks increased to 2.6 (95% CI, 1.3-5.3; p < 0.01) and 3.5 (95% CI, 1.3-9.3; p = 0.01), respectively.

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页码：409 / 412

页数：4

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