Polymorphism at codon 129 of the prion protein gene is not associated with sporadic AD

被引：55

作者：

Combarros, O ^{[1
]}

Sánchez-Guerra, M

Llorca, J

Alvarez-Arcaya, A

Berciano, J

Peña, N

Fernández-Viadero, C

机构：

[1] Univ Hosp Marques de Valdecilla, Neurol Serv, Santander 39008, Spain

[2] Univ Cantabria, Sch Med, Div Prevent Med, Santander, Spain

[3] RTE, Santander, Spain

[4] Consejaria Sanidad, Cantabria, Spain

来源：

NEUROLOGY | 2000年 / 55卷 / 04期

关键词：

D O I：

10.1212/WNL.55.4.593

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

An association between cognitive performance in elderly people and variability in the codon 129 of the prion protein gene (PRNP) has been recently described. The authors analyzed this polymorphism in 278 sporadic AD patients and 268 cognitively normal control subjects. Analyses stratifying by APOE genotype, age, and gender failed to reveal any association between homozygosity for the 129 PRNP methionine or valine alleles and AD.

引用

页码：593 / 595

页数：3

共 8 条

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