Schizophrenia -: an evolutionary enigma?

被引:60
作者
Brüne, M
机构
[1] Ruhr Univ Bochum, Ctr Psychiat & Psychotherapy, D-44791 Bochum, Germany
[2] Australian Natl Univ, Res Sch Biol Sci, Ctr Mind, Sydney, NSW, Australia
[3] Univ Sydney, Sydney, NSW, Australia
关键词
schizophrenia; genetics; human evolution; trade-off; dysconnectivity; brain maturation; heterochrony; language; social brain; catatonia; symptom-related approach;
D O I
10.1016/j.neubiorev.2003.10.002
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
The term 'schizophrenia' refers to a group of disorders that have been described in every human culture. Two apparently well established findings have corroborated the need for an evolutionary explanation of these disorders: (1) cross-culturally stable incidence rates and (2) decreased fecundity of the affected individuals. The rationale behind this relates to the evolutionary paradox that susceptibility genes for schizophrenia are obviously preserved in the human genepool, despite fundamental reproductive disadvantages associated with the disorders. Some researchers have therefore proposed that a compensatory advantage must exist in people who are carriers of these genes or in their first-degree relatives. Such advantages were hypothesised to be outside the brain (e.g. greater resistance against toxins or infectious diseases), or within the social domain (e.g. schizotypal shamans, creativity). More specifically, T.J. Crow has suggested an evolutionary theory of schizophrenia that relates the disorders to an extreme of variation of hemispheric specialisation and the evolution of language due to a single gene mutation located on homologous regions of the sex chromosomes. None of the evolutionary scenarios does, however, fully account for the diversity of the symptomatology, nor does any one hypothesis acknowledge the objection that the mere prevalence of a disorder must not be confused with adaptation. In the present article, I therefore discuss the evolutionary hypotheses of schizophrenia, arguing that a symptom-based approach to psychotic disorders in evolutionary perspective may improve upon the existing models of schizophrenia. (C) 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码:41 / 53
页数:13
相关论文
共 131 条
[21]   Toward an integration of interpersonal and biological processes:: Evolutionary psychiatry as an empirically testable framework for psychiatric research [J].
Brüne, M .
PSYCHIATRY-INTERPERSONAL AND BIOLOGICAL PROCESSES, 2002, 65 (01) :48-57
[22]   Social cognition and psychopathology in an evolutionary perspective -: Current status and proposals for research [J].
Brüne, M .
PSYCHOPATHOLOGY, 2001, 34 (02) :85-94
[23]  
Brune M., 2003, The Social Brain-Evolution and Pathology, P277, DOI DOI 10.1002/0470867221.CH13
[24]  
Brune M., 2000, Anthropology Medicine, V7, P301, DOI [https://doi.org/10.1080/713650607, DOI 10.1080/713650607]
[25]  
BURNS JK, 2003, IN PRESS BEHAV BRAIN
[26]  
Burton-Bradley B G, 1990, P N G Med J, V33, P51
[27]   Evidence for early-childhood, pan-developmental impairment specific to schizophreniform disorder - Results from a longitudinal birth cohort [J].
Cannon, M ;
Caspi, A ;
Moffitt, TE ;
Harrington, H ;
Taylor, A ;
Murray, RM ;
Poulton, R .
ARCHIVES OF GENERAL PSYCHIATRY, 2002, 59 (05) :449-456
[28]   POSSIBLE BIOLOGICAL ADVANTAGES AMONG SCHIZOPHRENICS RELATIVES [J].
CARTER, M ;
WATTS, CAH .
BRITISH JOURNAL OF PSYCHIATRY, 1971, 118 (545) :453-&
[29]   Association between promoter polymorphic haplotypes of interleukin-10 gene and schizophrenia [J].
Chiavetto, LB ;
Boin, F ;
Zanardini, R ;
Popoli, M ;
Michelato, A ;
Bignotti, S ;
Tura, GB ;
Gennarelli, M .
BIOLOGICAL PSYCHIATRY, 2002, 51 (06) :480-484
[30]   Dual cytoarchitectonic trends: An evolutionary model of frontal lobe functioning and its application to psychopathology [J].
Christensen, BK ;
Bilder, RM .
CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE, 2000, 45 (03) :247-256