Synthesis of Oxindoles by Tandem Heck-Reduction-Cyclization (HRC) from a Single Bifunctional, in Situ Generated Pd/C Catalyst

被引：96

作者：

Felpin, Francois-Xavier ^{[1
]}

Ibarguren, Oier ^{[1
]}

Nassar-Hardy, Luma ^{[1
]}

Fouquet, Eric ^{[1
]}

机构：

[1] Univ Bordeaux, CNRS, Inst Mol Sci, F-33405 Talence, France

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2009年 / 74卷 / 03期

关键词：

ARENEDIAZONIUM TETRAFLUOROBORATE SALTS; REVERSE-TRANSCRIPTASE INHIBITORS; ONE-POT SYNTHESIS; HETEROGENEOUS CATALYST; BIOLOGICAL EVALUATIONS; SUBSTITUTION-REACTIONS; ARYLDIAZONIUM SALTS; ORGANIC-SYNTHESIS; DOMINO REACTIONS; TYROSINE KINASE;

D O I：

10.1021/jo802467s

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A tandem sequence involving palladium-catalyzed sequential Heck-reduction-cyclization transformations in mild conditions has been developed for the synthesis of oxindoles. The protocol involves inexpensive reagents and does not require any additives such as base or ligands.

引用

页码：1349 / 1352

页数：4

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