Heterogeneous palladium catalysts for a new one-pot chemical route in the synthesis of fragrances based on the Heck reaction

被引：61

作者：

Climent, Maria Jose ^{[1
]}

Corma, Avelino ^{[1
]}

Iborra, Sara ^{[1
]}

Mifsud, Maria ^{[1
]}

机构：

[1] Univ Politecn Valencia, CSIC, Inst Tecnol Quim, Valencia 46022, Spain

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2007年 / 349卷 / 11-12期

关键词：

fragrances; Heck reaction; one-pot reaction; palladium; raspberry scent; supported catalysts;

D O I：

10.1002/adsc.200700026

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The one-pot synthesis of the fragrance 4(p-methoxyphenyl)butan-2-one, with raspberry scent, has been carried out using palladium on different supports such as magnesium oxide (MgO), hydrotalcite, hydroxyapatite (HA), aluminium oxide (gamma-Al2O3) and titanium dioxide (TiO2). The first pathway consists of a Heck coupling between 4-methoxyiodoanisole and methyl vinyl ketone followed by hydrogenation. Palladium supported on titanium di-oxide showed the best performance for carrying out both consecutive steps giving 4-(p-methoxyphenyl)butan-2-one with high yields and selectivity. The Pd-TiO2 catalyst is more active than a homogeneous palladium complex that is well accepted in the literature as being highly active for performing Heck reactions.

引用

页码：1949 / 1954

页数：6

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