Endothelial dysfunction in type 2 diabetes mellitus

被引:87
作者
Avogaro, A [1 ]
Fadini, GP [1 ]
Gallo, A [1 ]
Pagnin, E [1 ]
de Kreutzenberg, S [1 ]
机构
[1] Univ Padua, Sch Med, Dept Clin & Expt Med, Div Metab Dis, I-35128 Padua, Italy
关键词
endothelium; diabetes; protein kinase C; diabetic complications; cardiovascular disease;
D O I
10.1016/j.numecd.2005.10.015
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Aims: Vascular endothelial cells play a major role in maintaining cardiovascular homeostasis in health. Diabetes mellitus (DM) substantially impairs the vasodilating properties of the endothelium and leads to endothelial dysfunction, which can thus be considered the first step in the progression of cardiovascular disease. The aim of the present study is to illustrate possible mechanisms responsible for endothelial dysfunction in DM. Data synthesis: We have shown that NADPH oxidase gene expression is increased in circulating lymphomonocytes from patients with DM, and that this increased gene expression is dependent upon metabolic control. Hyperglycemia can mediate its adverse effects through the activation of protein kinase C. We have shown an increase in membrane-associated PKC beta 2 activity in monocytes from patients with DM. This activity was reduced by 40% in the euglycemic condition. Finally, we show a reduction of the circulating enclothelial progenitor cells, a subset of bone marrow-derived endotheliat-oriented stem cells, which can give rise to mature endothelial cells. Conclusion: Endothelial dysfunction, the initial step of the atherosclerotic process, is reversible. Thus, major efforts should be made to control not only hyperglycemia but also the other risk factors for cardiovascular disease, in order to prevent the onset of all these processes that eventually leads the diabetic patient to premature death. (c) 2005 Elsevier B.V. All rights reserved.
引用
收藏
页码:S39 / S45
页数:7
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