Synthesis and antimycobacterial activity of new S-alkylisothiosemicarbazone derivatives

被引：56

作者：

Cocco, MT

Congiu, C

Onnis, V

Pellerano, ML

De Logu, A

机构：

[1] Univ Cagliari, Dipartimento Tossicol, I-09124 Cagliari, Italy

[2] Univ Cagliari, Dipartimento Sci Chirurg & Trapianti Organo, Sez Microbiol & Virol, I-09123 Cagliari, Italy

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2002年 / 10卷 / 03期

关键词：

D O I：

10.1016/S0968-0896(01)00310-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

A new series of S-alkylisothiosemicarbazones of 3- and 4-pyridincarboxaldehyde and 4-fluoro- and 4-trifluoromethylbenzaldehyde was synthesized and evaluated for biological activity against various Mycobacterium strains. Inhibitory activity against Mycobacterium tuberculosis H37Rv ATCC 27294 and INH-R ATCC 35822 was compared with activity against clinical isolated Mycobacteria as well as against MOTT. Some of newly prepared compounds showed best inhibitory values against clinical isolated Mycobacteria, besides to low citotoxicity values. (C) 2002 Elsevier Science Ltd. All rights reserved.

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收藏

页码：501 / 506

页数：6

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