Small molecules targeting p53 to improve antitumor therapy

被引：12

作者：

Beretta, G. L. ^{[1
]}

Gatti, L. ^{[1
]}

Benedetti, V. ^{[1
]}

Perego, P. ^{[1
]}

Zunino, F. ^{[1
]}

机构：

[1] Ist Nazl Tumori, Fdn IRCCS, Dept Expt Oncol & Labs, I-20133 Milan, Italy

来源：

MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2008年 / 8卷 / 09期

关键词：

p53; nutlins; pifithrins; histone deacetylase inhibitors; ubiquitin ligase inhibitors; apoptosis; cancer cells; drug combination;

D O I：

10.2174/138955708785132774

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Small molecules targeting p53 represent an emerging group of potentially useful agents for the improvement of antitumor therapy. These modulators include agents that activate wild-type p53 or reactivate mutant p53 and inhibitors of p53 functions. Preclinical evidences support the interest of combination strategies with conventional antitumor agents.

引用

页码：856 / 868

页数：13

共 100 条

[31] TUMORIGENIC POTENTIAL ASSOCIATED WITH ENHANCED EXPRESSION OF A GENE THAT IS AMPLIFIED IN A MOUSE-TUMOR CELL-LINE [J].

FAKHARZADEH, SS ;

TRUSKO, SP ;

GEORGE, DL .

EMBO JOURNAL, 1991, 10 (06) :1565-1569

[32]

Fang BL, 2003, CANCER BIOL THER, V2, pS115

[33]

Feldherr CM, 2001, J CELL SCI, V114, P4621

[34] Pharmacological rescue of mutant p53 conformation and function [J].

Foster, BA ;

Coffey, HA ;

Morin, MJ ;

Rastinejad, F .

SCIENCE, 1999, 286 (5449) :2507-2510

[35] Classic and novel roles of p53:: prospects for anticancer therapy [J].

Fuster, Jose J. ;

Sanz-Gonzalez, Silvia M. ;

Moll, Ute M. ;

Andres, Vicente .

TRENDS IN MOLECULAR MEDICINE, 2007, 13 (05) :192-199

[36] A nonpeptidic sulfonamide inhibits the p53-mdm2 interaction and activates p53-dependent transcription in mdm2-overexpressing cells [J].

Galatin, PS ;

Abraham, DJ .

JOURNAL OF MEDICINAL CHEMISTRY, 2004, 47 (17) :4163-4165

[37] The p53 inhibitor pifithrin-α forms a sparingly soluble derivative via intramolecular cyclization under physiological conditions [J].

Gary, Ronald K. ;

Jensen, Derek A. .

MOLECULAR PHARMACEUTICS, 2005, 2 (06) :462-474

[38] Prospective therapeutic applications of p53 inhibitors [J].

Gudkov, AV ;

Komarova, EA .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2005, 331 (03) :726-736

[39]

Hainaut P, 2000, ADV CANCER RES, V77, P81

[40] Mdm2 promotes the rapid degradation of p53 [J].

Haupt, Y ;

Maya, R ;

Kazaz, A ;

Oren, M .

NATURE, 1997, 387 (6630) :296-299

← 1 2 3 4 5 6 7 8 9 10 →