The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic Treg Cell Homeostasis

被引：5081

作者：

Smith, Patrick M. ^{[1
,2
]}

Howitt, Michael R. ^{[1
,2
]}

Panikov, Nicolai ^{[1
,2
]}

Michaud, Monia ^{[1
,2
]}

Gallini, Carey Ann ^{[1
,2
]}

Bohlooly-Y, Mohammad ^{[6
]}

Glickman, Jonathan N. ^{[7
,8
]}

Garrett, Wendy S. ^{[1
,2
,3
,4
,5
]}

机构：

[1] Harvard Univ, Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA 02115 USA

[2] Harvard Univ, Sch Publ Hlth, Dept Genet & Complex Dis, Boston, MA 02115 USA

[3] Harvard Univ, Sch Med, Dept Med, Boston, MA USA

[4] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA

[5] Broad Inst Harvard & MIT, Cambridge, MA USA

[6] AstraZeneca, RAD Transgen, Molndal, Sweden

[7] Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA

[8] Miraca Life Sci, Newton, MA USA

来源：

SCIENCE | 2013年 / 341卷 / 6145期

关键词：

LARGE-INTESTINE; GUT MICROBIOTA; DIVERSITY; INFLAMMATION; INHIBITION; RECEPTOR; PROTECT; MICE;

D O I：

10.1126/science.1241165

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

Regulatory T cells (T-regs) that express the transcription factor Foxp3 are critical for regulating intestinal inflammation. Candidate microbe approaches have identified bacterial species and strain-specific molecules that can affect intestinal immune responses, including species that modulate T-reg responses. Because neither all humans nor mice harbor the same bacterial strains, we posited that more prevalent factors exist that regulate the number and function of colonic T-regs. We determined that short-chain fatty acids, gut microbiota-derived bacterial fermentation products, regulate the size and function of the colonic T-reg pool and protect against colitis in a Ffar2-dependent manner in mice. Our study reveals that a class of abundant microbial metabolites underlies adaptive immune microbiota coadaptation and promotes colonic homeostasis and health.

引用

页码：569 / 573

页数：5

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