Copy number alterations unmasked as enhancer hijackers

被引：31

作者：

Beroukhim, Rameen ^{[1
,2
]}

Zhang, Xiaoyang ^{[1
,2
]}

Meyerson, Matthew ^{[1
,2
]}

机构：

[1] Broad Inst Harvard & MIT, Dana Farber Canc Inst, Boston, MA USA

[2] Harvard Med Sch, Boston, MA USA

来源：

NATURE GENETICS | 2017年 / 49卷 / 01期

关键词：

PROSTATE-CANCER; GENE; NEIGHBORHOODS;

D O I：

10.1038/ng.3754

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Our understanding of how DNA copy number changes contribute to disease, including cancer, has to a large degree been focused on the changes in gene dosage that they generate and has neglected the effects of the DNA rearrangements that lead to their formation. A new study reports an innovative analytical framework for copy number alterations that are oncogenic primarily owing to the genomic rearrangements that underlie them.

引用

页码：5 / 6

页数：2

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