Mechanistic principles in chiral separations using liquid chromatography and capillary electrophoresis

被引：81

作者：

Ali, I

Kumerer, K

Aboul-Enein, HY ^{[1
]}

机构：

[1] Natl Res Ctr, Pharmaceut & Med Chem Dept, Pharmaceut & Drug Ind Res Div, Cairo 12311, Egypt

[2] Univ Hosp Freiburg, Inst Environm Med & Hosp Epidemiol, D-79106 Freiburg, Germany

[3] Natl Inst Hydrol, Roorkee 247667, Uttar Pradesh, India

来源：

CHROMATOGRAPHIA | 2006年 / 63卷 / 7-8期

关键词：

liquid chromatography; capillary electrophoresis; chiral separation; mechanisms in CE;

D O I：

10.1365/s10337-006-0762-5

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Due to the importance of chiral separations of drugs, pharmaceuticals, agrochemicals and xenobiotics by high performance liquid chromatography (HPLC) and capillary electrophoresis (CE), it is important to have the knowledge of the enantiomeric recognition mechanisms so that scientists may design and module the new chiral selectors for rapid, inexpensive and reproducible chiral separations; specially at preparative scale. The mechanisms of the chiral separation by HPLC and CE using polysaccharides, cyclodextrins, macrocyclic glycopeptide antibiotics, Pirkle type, ligand exchangers, crown ethers and other several types of chiral selectors have been discussed. Various complex formation and different types of interactions responsible for chiral resolution have been presented in detail.

引用

页码：295 / 307

页数：13

共 152 条

[1]

Aboul-Enein H. Y., 2003, CHIRAL SEPARATIONS L

[2] Effect of acidity on the enantiomeric resolution of thyroxine and tocainide by HPLC on a (+)-(18-crown-6)-2,3,11,12-tetracarboxylic acid column [J].