Drug targeting to the colon with lectins and neoglycoconjugates

被引：173

作者：

Minko, T ^{[1
]}

机构：

[1] Rutgers State Univ, Ernest Mario Sch Pharm, Dept Pharmaceut, Piscataway, NJ 08854 USA

来源：

ADVANCED DRUG DELIVERY REVIEWS | 2004年 / 56卷 / 04期

关键词：

colon cancer; targeted drug delivery; prodrug; polymers; liposomes; review;

D O I：

10.1016/j.addr.2003.10.017

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Targeting of drugs to specific sites of action provides several advantages over non-targeted drugs. These include the prevention of side effects of drugs on healthy tissues and enhancement of drug uptake by targeted cells. This review will cover traditional approaches of colon drug targeting as well as the use of lectins and neoglycoconjugates for the targeted delivery. Direct and reverse targeting strategies, potential molecular targets and targeting moieties for colon drug delivery, targeted drug delivery systems (DDS) for colon delivery, anticancer DDS targeted to colon cancer are examined. Directions of future development are discussed. (C) 2003 Elsevier B.V. All rights reserved.

引用

页码：491 / 509

页数：19

共 105 条

[21] Glycohistochemistry: The why and how of detection and localization of endogenous lectins [J].

Gabius, HJ .

ANATOMIA HISTOLOGIA EMBRYOLOGIA, 2001, 30 (01) :3-31

[22] Lectin-mediated drug delivery: binding and uptake of BSA-WGA conjugates using the Caco-2 model [J].

Gabor, F ;

Schwarzbauer, A ;

Wirth, M .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2002, 237 (1-2) :227-239

[23]

Galanina O, 1998, INT J CANCER, V76, P136

[24] BCL-2 family members and the mitochondria in apoptosis [J].

Gross, A ;

McDonnell, JM ;

Korsmeyer, SJ .

GENES & DEVELOPMENT, 1999, 13 (15) :1899-1911

[25] Gut flora in health and disease [J].

Guarner, F ;

Malagelada, JR .

LANCET, 2003, 361 (9356) :512-519

[26] Gastric emptying time and the effect of cisapride in cirrhotic patients with autonomic neuropathy [J].

Gumurdulu, Y ;

Yapar, Z ;

Canataroglu, A ;

Serin, E ;

Gumurdulu, D ;

Kibar, M ;

Çolakoglu, S .

JOURNAL OF CLINICAL GASTROENTEROLOGY, 2003, 36 (02) :175-178

[27]

Herrera-Ruiz D, 2001, AAPS PHARMSCI, V3

[28] Upregulation of galectins-1 and-3 in human colon cancer and their role in regulating cell migration [J].

Hittelet, A ;

Legendre, H ;

Nagy, N ;

Bronckart, Y ;

Pector, JC ;

Salmon, I ;

Yeaton, P ;

Gabius, HJ ;

Kiss, R ;

Camby, I .

INTERNATIONAL JOURNAL OF CANCER, 2003, 103 (03) :370-379

[29] Bak BH3 peptides antagonize Bcl-xL function and induce apoptosis through cytochrome c-independent activation of caspases [J].

Holinger, EP ;

Chittenden, T ;

Lutz, RJ .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (19) :13298-13304

[30] Diethyl ether fraction of Labrasol having a stronger absorption enhancing effect on gentamicin than Labrasol itself [J].

Hu, ZP ;

Prasad, R ;

Tawa, R ;

Konishi, T ;

Ishida, M ;

Shibata, N ;

Takada, K .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2002, 234 (1-2) :223-235

← 1 2 3 4 5 6 7 8 9 10 →