A rapid and facile method for the dereplication of purified natural products

被引：40

作者：

Bradshaw, J

Butina, D

Dunn, AJ

Green, RH

Hajek, M

Jones, MM

Lindon, JC

Sidebottom, PJ

机构：

[1] GlaxoSmithKline Med Res Ctr, Stevenage SG1 2NY, Herts, England

[2] Univ London Imperial Coll Sci Technol & Med, Div Biol Sci, London SW7 2AZ, England

来源：

JOURNAL OF NATURAL PRODUCTS | 2001年 / 64卷 / 12期

关键词：

D O I：

10.1021/np010284g

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A new approach to the use of commercial databases for the dereplication of purified natural products has been developed. This is based on searching a text file that links each structure with its molecular weight and an exact count of the number of methyl, methylene, and methine groups it contains. Analysis of such a text file, constructed from a database containing more than 126 000 natural product structures, revealed that these data, readily measured using MS and NMR spectroscopy, are highly discriminating. The identification of an alkaloid and a sesquiterpene using this new approach is described.

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页码：1541 / 1544

页数：4

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