Advances in the structure and chemistry of metallothioneins

被引：225

作者：

Romero-Isart, N ^{[1
]}

Vasák, M ^{[1
]}

机构：

[1] Univ Zurich, Inst Biochem, CH-8057 Zurich, Switzerland

来源：

JOURNAL OF INORGANIC BIOCHEMISTRY | 2002年 / 88卷 / 3-4期

关键词：

metallothionein; protein structure; metal-thiolate clusters; structure dynamics; thiol reactivity;

D O I：

10.1016/S0162-0134(01)00347-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A low molecular weight (6-7 kDa) class of metalloproteins, designated as metallothioneins (MTs), exhibit repeated sequence motifs of either CxC or CxxC through which mono or divalent d(10) metal ions are bound in polymetallic-thiolate clusters. The preservation of metal-thiolate clusters in an increasing number of three-dimensional structures of these proteins signifies the importance of this structural motif. This review focuses on the recent developments regarding the versatile and striking chemical reactivity of MTs as well as on the existence of conformational/configurational dynamics within their structure. Both properties and their interplay are likely to be essential for the still elusive biological function of these proteins. (C) 2002 Elsevier Science Inc. All rights reserved.

引用

页码：388 / 396

页数：9

共 91 条

[21] Distinct metal-thiolate clusters in the N-terminal domain of neuronal growth inhibitory factor [J].

Faller, P ;

Vasak, M .

BIOCHEMISTRY, 1997, 36 (43) :13341-13348

[22] Evidence for a dynamic structure of human neuronal growth inhibitory factor and for major rearrangements of its metal -: Thiolate clusters [J].

Faller, P ;

Hasler, DW ;

Zerbe, O ;

Klauser, S ;

Winge, DR ;

Vasák, M .

BIOCHEMISTRY, 1999, 38 (31) :10158-10167

[23] A PULSE RADIOLYTIC STUDY ON THE REACTION OF HYDROXYL AND SUPEROXIDE RADICALS WITH YEAST CU(I)-THIONEIN [J].

FELIX, K ;

LENGFELDER, E ;

HARTMANN, HJ ;

WESER, U .

BIOCHIMICA ET BIOPHYSICA ACTA, 1993, 1203 (01) :104-108

[24] REACTION OF CD-111(7)-METALLOTHIONEIN WITH EDTA - A REAPPRAISAL [J].

GAN, T ;

MUNOZ, A ;

SHAW, CF ;

PETERING, DH .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (10) :5339-5345

[25] Methylation of tethered thiolates in [(bme-daco)Zn]2 and [(bme-daco)Cd]2 as a model of zinc sulfur-methylation proteins [J].

Grapperhaus, CA ;

Tuntulani, T ;

Reibenspies, JH ;

Darensbourg, MY .

INORGANIC CHEMISTRY, 1998, 37 (16) :4052-4058

[26] Mobility of copper in binding sites in rabbit liver metallothionein 2 [J].

Green, AR ;

Stillman, MJ .

INORGANIC CHEMISTRY, 1996, 35 (10) :2799-2807

[27] METAL-ION EXCHANGE-REACTIONS IN CAGE MOLECULES - THE SYSTEMS [M4-ETAM'ETA(SC6H5)10]2- (M, M' = FE(II), CO(II), ZN(II), CD(II)) WITH ADAMANTANE-LIKE STEREOCHEMISTRY AND THE STRUCTURE OF [FE4(SC6H5)10]2- [J].

HAGEN, KS ;

STEPHAN, DW ;

HOLM, RH .

INORGANIC CHEMISTRY, 1982, 21 (11) :3928-3936

[28] Methylation of (2-methylethanethiol-bis-3,5-dimethylpyrazolyl)methane zinc complexes and coordination of the resulting thioether: Relevance to zinc-containing alkyl transfer enzymes [J].

Hammes, BS ;

Carrano, CJ .

INORGANIC CHEMISTRY, 2001, 40 (05) :919-927

[29] Copper-release from yeast Cu(I)-metallothionein by nitric oxide (NO) [J].

Hartmann, HJ ;

Weser, U .

BIOMETALS, 2000, 13 (02) :153-156

[30] Metal-thiolate clusters in the C-terminal domain of human neuronal growth inhibitory factor (GIF) [J].

Hasler, DW ;

Faller, P ;

Vasak, M .

BIOCHEMISTRY, 1998, 37 (42) :14966-14973

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