Spotless rickettsiosis caused by Rickettsia slovaca and associated with Dermacentor ticks

被引:135
作者
Raoult, D
Lakos, A
Fenollar, F
Beytout, J
Brouqui, P
Fournier, PE
机构
[1] Univ Mediterranee, Fac Med, Unite Rickettsies, CNRS,UPRESA 6020,IFR 48, F-13385 Marseille 05, France
[2] Hop Hotel Dieu, Serv Malad Infect, Clermont Ferrand, France
[3] Ctr Tickborne Dis, Budapest, Hungary
关键词
D O I
10.1086/340100
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The pathogenic role of Rickettsia slovaca was first demonstrated in 1997 in a patient who presented with a single inoculation lesion of the scalp and enlarged cervical lymph nodes after receiving a bite from a Dermacentor tick. Subsequently, we evaluated the occurrence of R. slovaca infections among patients living in France and Hungary who presented with these symptoms. R. slovaca infections were confirmed by polymerase chain reaction (PCR) in 17 of 67 enrolled patients. Infections were most likely to occur in patients aged <10 years and in patients who were bitten during the colder months of the year. The median duration of incubation for the disease was 7 days. Fever was present in only 2 patients, and only 1 patient developed a rash. Sequelae included persistent asthenia (3 cases) and localized alopecia (4 cases). Immunofluorescence and/or Western blot analysis detected antibodies in 50% of tested patients. Three Dermacentor ticks obtained from patients revealed R. slovaca by PCR.
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收藏
页码:1331 / 1336
页数:6
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