Cloning and biochemical characterization of FOX-5, an AmpC-type plasmid-encoded β-lactamase from a New York City Klebsiella pneumoniae clinical isolate

被引：34

作者：

Queenan, AM ^{[1
]}

Jenkins, S

Bush, K

机构：

[1] RW Johnson Pharmaceut Res Inst, Raritan, NJ 08869 USA

[2] Mt Sinai Hosp, New York, NY 10029 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2001年 / 45卷 / 11期

关键词：

D O I：

10.1128/AAC.45.11.3189-3194.2001

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Klebsiella pneumoniae 5064, isolated in New York, carried plasmid-mediated resistance to multiple beta -lactams and was unresponsive to clavulanic acid. The beta -lactamase gene responsible for cephalosporin resistance encoded FOX-5, with 96 to 97% amino acid identities to other members of the FOX family of beta -lactamases. The bla(FOX-5) coding region was located next to a transposase gene from the Aeromonas salmonicida insertion element ISAS2.

引用

页码：3189 / 3194

页数：6

共 24 条

[1] Comparative characterization of the cephamycinase bla(CMY-1) gene and its relationship with other beta-lactamase genes [J].

Bauernfeind, A ;

Stemplinger, I ;

Jungwirth, R ;

Wilhelm, R ;

Chong, Y .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1996, 40 (08) :1926-1930

[2] A novel type of AmpC β-lactamase, ACC-1, produced by a Klebsiella pneumoniae strain causing nosocomial pneumonia [J].

Bauernfeind, A ;

Schneider, I ;

Jungwirth, R ;

Sahly, H ;

Ullmann, U .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1999, 43 (08) :1924-1931

[3] A novel class C beta-lactamase (FOX-2) in Escherichia coli conferring resistance to cephamycins [J].

Bauernfeind, A ;

Wagner, S ;

Jungwirth, R ;

Schneider, I ;

Meyer, D .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1997, 41 (09) :2041-2046

[4] Molecular characterization of FOX-4, a new ampC-type plasmid-mediated β-lactamase from an Escherichia coli strain isolated in Spain [J].

Bou, G ;

Oliver, A ;

Ojeda, M ;

Monzón, C ;

Martínez-Beltrán, J .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2000, 44 (09) :2549-2553

[5] Imipenem resistance in Klebsiella pneumoniae is associated with the combination of ACT-1, a plasmid-mediated AmpC beta-lactamase, and the loss of an outer membrane protein [J].

Bradford, PA ;

Urban, C ;

Mariano, N ;

Projan, SJ ;

Rahal, JJ ;

Bush, K .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1997, 41 (03) :563-569

[6] EFFECTIVE COOLING ALLOWS SONICATION TO BE USED FOR LIBERATION OF BETA-LACTAMASES FROM GRAM-NEGATIVE BACTERIA [J].

BUSH, K ;

SINGER, SB .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1989, 24 (01) :82-84

[7] A FUNCTIONAL CLASSIFICATION SCHEME FOR BETA-LACTAMASES AND ITS CORRELATION WITH MOLECULAR-STRUCTURE [J].

BUSH, K ;

JACOBY, GA ;

MEDEIROS, AA .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1995, 39 (06) :1211-1233

[8] Occurrence and detection of AmpC beta-lactamases among Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis isolates at a Veterans Medical Center [J].

Coudron, PE ;

Moland, ES ;

Thomson, KS .

JOURNAL OF CLINICAL MICROBIOLOGY, 2000, 38 (05) :1791-1796

[9] GRAPHICAL DETERMINATION OF KM AND KI [J].

DIXON, M .

BIOCHEMICAL JOURNAL, 1972, 129 (01) :197-&

[10] CLONING AND SEQUENCE-ANALYSIS OF BLA(BIL-1), A PLASMID-MEDIATED CLASS-C BETA-LACTAMASE GENE IN ESCHERICHIA-COLI BS [J].

FOSBERRY, AP ;

PAYNE, DJ ;

LAWLOR, EJ ;

HODGSON, JE .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1994, 38 (05) :1182-1185

← 1 2 3 →