Cloning and biochemical characterization of FOX-5, an AmpC-type plasmid-encoded β-lactamase from a New York City Klebsiella pneumoniae clinical isolate

被引：34

作者：

Queenan, AM ^{[1
]}

Jenkins, S

Bush, K

机构：

[1] RW Johnson Pharmaceut Res Inst, Raritan, NJ 08869 USA

[2] Mt Sinai Hosp, New York, NY 10029 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2001年 / 45卷 / 11期

关键词：

D O I：

10.1128/AAC.45.11.3189-3194.2001

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Klebsiella pneumoniae 5064, isolated in New York, carried plasmid-mediated resistance to multiple beta -lactams and was unresponsive to clavulanic acid. The beta -lactamase gene responsible for cephalosporin resistance encoded FOX-5, with 96 to 97% amino acid identities to other members of the FOX family of beta -lactamases. The bla(FOX-5) coding region was located next to a transposase gene from the Aeromonas salmonicida insertion element ISAS2.

引用

页码：3189 / 3194

页数：6

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