Relation between plasma endothelin 1 levels and T helper 1:T helper 2 cell immunity in women with preeclampsia

被引：8

作者：

Kuwajima, T ^{[1
]}

Suzuki, S ^{[1
]}

Yoneyama, Y ^{[1
]}

Sawa, R ^{[1
]}

Asakura, H ^{[1
]}

Araki, T ^{[1
]}

机构：

[1] Nippon Med Coll, Dept Obstet & Gynecol, Bunkyo Ku, Tokyo 1138603, Japan

来源：

GYNECOLOGIC AND OBSTETRIC INVESTIGATION | 2001年 / 52卷 / 04期

关键词：

endothelin; 1; Th1; Th2; preeclampsia;

D O I：

10.1159/000052987

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

The aim of this study was to investigate the relationship between plasma endothelin 1 (ET-1) levels and T helper (Th)-1:Th2 cell immunity in women with preeclampsia. The percentage of Th1 and Th2 cells and the Th1:Th2 cell ratios in peripheral blood from 11 normal pregnant women and 11 patients with preeclampsia at 29-34 weeks of gestation were calculated using flow cytometry. The plasma ET-1 level was also determined using a modified radioimmunoassay. The plasma ET-1 concentrations and the Th1:Th2 cell ratios in normal pregnancies were significantly lower than those in patients with preeclampsia. Negative correlations were found between plasma ET-1 levels and Th2 cells in both the preeclamptic pregnancy groups and in the normal pregnant women. Our results indicate that elevated ET-1 levels are associated with a Th1:Th2 imbalance in preeclampsia. Copyright (C) 2001 S. Karger AG, Basel.

引用

页码：260 / 263

页数：4

共 24 条

[1]

Akahoshi M, 1995, ARTHRITIS RHEUM, V38, P1832

[2] PRESENCE OF IMMUNOREACTIVE ENDOTHELIN IN HUMAN-PLASMA [J].

ANDO, K ;

HIRATA, Y ;

SHICHIRI, M ;

EMORI, T ;

MARUMO, F .

FEBS LETTERS, 1989, 245 (1-2) :164-166

[3]

ASCHKENAZI S, 2001, J SOC GYNECOL INVEST, V8, P114

[4] The immunology of preeclampsia [J].

Dekker, GA ;

Sibai, BM .

SEMINARS IN PERINATOLOGY, 1999, 23 (01) :24-33

[5]

EGGER D, 1995, J IMMUNOL, V154, P1830

[6]

FRIEDMAN SA, 1995, CLIN PERINATOL, V22, P343

[7] Changes in plasma soluble CD26 and CD30 during pregnancy: Markers of Th1/Th2 balance? [J].

Hoshimoto, K ;

Ohta, N ;

Ohkura, T ;

Inaba, N .

GYNECOLOGIC AND OBSTETRIC INVESTIGATION, 2000, 50 (04) :260-263

[8] HUMAN TROPHOBLAST AND JEG CHORIOCARCINOMA CELLS ARE SENSITIVE TO LYSIS BY IL-2-STIMULATED DECIDUAL NK CELLS [J].

KING, A ;

LOKE, YW .

CELLULAR IMMUNOLOGY, 1990, 129 (02) :435-448

[9] Characterization of type 1 and type 2 cytokine production profile in physiologic and pathologic human pregnancy [J].

Marzi, M ;

Vigano, A ;

Trabattoni, D ;

Villa, ML ;

Salvaggio, A ;

Clerici, E ;

Clerici, M .

CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 1996, 106 (01) :127-133

[10] POTENTIAL ROLE OF ENDOTHELIN-1 IN NORMAL AND HYPERTENSIVE PREGNANCIES [J].

MASTROGIANNIS, DS ;

OBRIEN, WF ;

KRAMMER, J ;

BENOIT, R .

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1991, 165 (06) :1711-1716

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