Relation between plasma endothelin 1 levels and T helper 1:T helper 2 cell immunity in women with preeclampsia

被引：8

作者：

Kuwajima, T ^{[1
]}

Suzuki, S ^{[1
]}

Yoneyama, Y ^{[1
]}

Sawa, R ^{[1
]}

Asakura, H ^{[1
]}

Araki, T ^{[1
]}

机构：

[1] Nippon Med Coll, Dept Obstet & Gynecol, Bunkyo Ku, Tokyo 1138603, Japan

来源：

GYNECOLOGIC AND OBSTETRIC INVESTIGATION | 2001年 / 52卷 / 04期

关键词：

endothelin; 1; Th1; Th2; preeclampsia;

D O I：

10.1159/000052987

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

The aim of this study was to investigate the relationship between plasma endothelin 1 (ET-1) levels and T helper (Th)-1:Th2 cell immunity in women with preeclampsia. The percentage of Th1 and Th2 cells and the Th1:Th2 cell ratios in peripheral blood from 11 normal pregnant women and 11 patients with preeclampsia at 29-34 weeks of gestation were calculated using flow cytometry. The plasma ET-1 level was also determined using a modified radioimmunoassay. The plasma ET-1 concentrations and the Th1:Th2 cell ratios in normal pregnancies were significantly lower than those in patients with preeclampsia. Negative correlations were found between plasma ET-1 levels and Th2 cells in both the preeclamptic pregnancy groups and in the normal pregnant women. Our results indicate that elevated ET-1 levels are associated with a Th1:Th2 imbalance in preeclampsia. Copyright (C) 2001 S. Karger AG, Basel.

引用

页码：260 / 263

页数：4

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