Tectonic, a novel regulator of the Hedgehog pathway required for both activation and inhibition

被引：94

作者：

Reiter, JF ^{[1
]}

Skarnes, WC

机构：

[1] Univ Calif San Francisco, Dev & Stem Cell Biol Program, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Ctr Diabet, San Francisco, CA 94143 USA

[3] Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley, CA 94720 USA

来源：

GENES & DEVELOPMENT | 2006年 / 20卷 / 01期

关键词：

Shh; signal transduction; mouse development; neural patterning; open brain;

D O I：

10.1101/gad.1363606

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

We report the identification of a novel protein that participates in Hedgehog-mediated patterning of the neural tube. This protein, named Tectonic, is the founding member of a previously undescribed family of evolutionarily conserved secreted and transmembrane proteins. During neural tube development, mouse Tectonic is required for formation of the most ventral cell types and for full Hedgehog (Hh) pathway activation. Epistasis analyses reveal that Tectonic modulates Hh signal transduction downstream of Smoothened (Smo) and Rab23. Interestingly, characterization of Tectonic Shh and Tectonic Smo double mutants indicates that Tectonic plays an additional role in repressing Hh pathway activity.

引用

页码：22 / 27

页数：6

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