Tectonic, a novel regulator of the Hedgehog pathway required for both activation and inhibition

被引：94

作者：

Reiter, JF ^{[1
]}

Skarnes, WC

机构：

[1] Univ Calif San Francisco, Dev & Stem Cell Biol Program, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Ctr Diabet, San Francisco, CA 94143 USA

[3] Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley, CA 94720 USA

来源：

GENES & DEVELOPMENT | 2006年 / 20卷 / 01期

关键词：

Shh; signal transduction; mouse development; neural patterning; open brain;

D O I：

10.1101/gad.1363606

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

We report the identification of a novel protein that participates in Hedgehog-mediated patterning of the neural tube. This protein, named Tectonic, is the founding member of a previously undescribed family of evolutionarily conserved secreted and transmembrane proteins. During neural tube development, mouse Tectonic is required for formation of the most ventral cell types and for full Hedgehog (Hh) pathway activation. Epistasis analyses reveal that Tectonic modulates Hh signal transduction downstream of Smoothened (Smo) and Rab23. Interestingly, characterization of Tectonic Shh and Tectonic Smo double mutants indicates that Tectonic plays an additional role in repressing Hh pathway activity.

引用

页码：22 / 27

页数：6

共 35 条

[21] Developmental roles and clinical significance of hedgehog signaling [J].

McMahon, AP ;

Ingham, PW ;

Tabin, CJ .

CURRENT TOPICS IN DEVELOPMENTAL BIOLOGY, VOL 53, 2003, 53 :1-114

[22]

Méthot N, 2000, DEVELOPMENT, V127, P4001

[23] Functional analysis of secreted and transmembrane proteins critical to mouse development [J].

Mitchell, KJ ;

Pinson, KI ;

Kelly, OG ;

Brennan, J ;

Zupicich, L ;

Scherz, P ;

Leighton, PA ;

Goodrich, LV ;

Lu, XW ;

Avery, BJ ;

Tate, P ;

Dill, K ;

Pangilinan, E ;

Wakenight, P ;

Tessier-Lavigne, M ;

Skarnes, WC .

NATURE GENETICS, 2001, 28 (03) :241-249

[24] Hedgehog elicits signal transduction by means of a large complex containing the kinesin-related protein costal2 [J].

Robbins, DJ ;

Nybakken, KE ;

Kobayashi, R ;

Sisson, JC ;

Bishop, JM ;

Therond, PP .

CELL, 1997, 90 (02) :225-234

[25] The zebrafish iguana locus encodes Dzip1, a novel zinc-finger protein required for proper regulation of Hedgehog signaling [J].

Sekimizu, K ;

Nishioka, N ;

Sasaki, H ;

Takeda, H ;

Karlstrom, RO ;

Kawakami, A .

DEVELOPMENT, 2004, 131 (11) :2521-2532

[26] Costal2, a novel kinesin-related protein in the Hedgehog signaling pathway [J].

Sisson, JC ;

Ho, KS ;

Suyama, K ;

Scott, MP .

CELL, 1997, 90 (02) :235-245

[27] CAPTURING GENES ENCODING MEMBRANE AND SECRETED PROTEINS IMPORTANT FOR MOUSE DEVELOPMENT [J].

SKARNES, WC ;

MOSS, JE ;

HURTLEY, SM ;

BEDDINGTON, RSP .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (14) :6592-6596

[28] Accelerated publication -: Identification of a tetrameric hedgehog signaling complex [J].

Stegman, MA ;

Vallance, JE ;

Elangovan, G ;

Sosinski, J ;

Cheng, Y ;

Robbins, DJ .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (29) :21809-21812

[29] Dynamic expression of basic helix-loop-helix Olig family members: implication of Olig2 in neuron and oligodendrocyte differentiation and identification of a new member, Olig3 [J].

Takebayashi, H ;

Yoshida, S ;

Sugimori, M ;

Kosako, H ;

Kominami, R ;

Nakafuku, M ;

Nabeshima, Y .

MECHANISMS OF DEVELOPMENT, 2000, 99 (1-2) :143-148

[30]

Wang DH, 2001, AGRO FOOD IND HI TEC, V12, P14

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