Immunogenetic factors in HPV-associated cervical cancer: Influence on disease progression

被引：45

作者：

DugganKeen, MF

Keating, PJ

Stevens, FRA

Sinnott, P

Snijders, PJF

Walboomers, JMM

Davidson, S

Hunter, RD

Dyer, PA

Stern, PL

机构：

[1] CHRISTIE HOSP NATL HLTH SERV TRUST, PATERSON INST CANC RES, CRC, DEPT IMMUNOL, MANCHESTER M20 9BX, LANCS, ENGLAND

[2] ST MARYS HOSP, TISSUE TYPING LAB, MANCHESTER M13 0JH, LANCS, ENGLAND

[3] FREE UNIV AMSTERDAM HOSP, INST PATHOL, NL-1081 HV AMSTERDAM, NETHERLANDS

来源：

EUROPEAN JOURNAL OF IMMUNOGENETICS | 1996年 / 23卷 / 04期

关键词：

D O I：

10.1111/j.1744-313X.1996.tb00123.x

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

No HLA allele or specificity was significantly different in frequency between a group of 150 cervical cancer patients from north-west England and controls (corrected P values). HLA-DRB1*1501/DQB1*0602 was non-significantly increased, particularly among patients with HPV16-positive tumours. HLA-B7-positive patients had a significantly poorer clinical outcome than HLA-B7-negative patients. A significant component of the genotypic effect is down-regulation of HLA-B7 expression by the tumour cells.

引用

页码：275 / 284

页数：10

共 22 条

[1] HLA DR-DQ ASSOCIATIONS WITH CERVICAL-CARCINOMA SHOW PAPILLOMAVIRUS-TYPE SPECIFICITY [J].

APPLE, RJ ;

ERLICH, HA ;

KLITZ, W ;

MANOS, MM ;

BECKER, TM ;

WHEELER, CM .

NATURE GENETICS, 1994, 6 (02) :157-162

[2] LOSS OF MHC CLASS-I EXPRESSION IN CERVICAL CARCINOMAS [J].

CONNOR, ME ;

STERN, PL .

INTERNATIONAL JOURNAL OF CANCER, 1990, 46 (06) :1029-1034

[3] DIFFERENCES IN MHC AND TAP-1 EXPRESSION IN CERVICAL-CANCER LYMPH-NODE METASTASES AS COMPARED WITH THE PRIMARY TUMORS [J].

CROMME, FV ;

VANBOMMEL, PFJ ;

WALBOOMERS, JMM ;

GALLEE, MPW ;

STERN, PL ;

KENEMANS, P ;

HELMERHORST, TJM ;

STUKART, MJ ;

MEIJER, CJLM .

BRITISH JOURNAL OF CANCER, 1994, 69 (06) :1176-1181

[4]

DIMAIO D, 1991, ADV CANCER RES, V56, P133

[5]

DUGGANKEEN M, 1994, PAPILLOMAVIRUS REP, V5, P3

[6] THE ASSOCIATION OF AN HPV16 ONCOGENE VARIANT WITH HLA-B7 HAS IMPLICATIONS FOR VACCINE DESIGN IN CERVICAL-CANCER [J].

ELLIS, JRM ;

KEATING, PJ ;

BAIRD, J ;

HOUNSELL, EF ;

RENOUF, DV ;

ROWE, M ;

HOPKINS, D ;

DUGGANKEEN, MF ;

BARTHOLOMEW, JS ;

YOUNG, LS ;

STERN, PL .

NATURE MEDICINE, 1995, 1 (05) :464-470

[7] NATURAL-HISTORY OF HLA EXPRESSION DURING TUMOR-DEVELOPMENT [J].

GARRIDO, F ;

CABRERA, T ;

CONCHA, A ;

GLEW, S ;

RUIZCABELLO, F ;

STERN, PL .

IMMUNOLOGY TODAY, 1993, 14 (10) :491-499

[8]

GLEW SS, 1992, NATURE, V356, P22, DOI 10.1038/356022a0

[9]

GLEW SS, 1993, HUM IMMUNOL, V37, P157, DOI 10.1016/0198-8859(93)90181-Y

[10] ASSOCIATION BETWEEN HLA-DQB1 ALLELES AND RISK FOR CERVICAL-CANCER IN AFRICAN-AMERICAN WOMEN [J].

GREGOIRE, L ;

LAWRENCE, WD ;

KUKURUGA, D ;

EISENBREY, AB ;

LANCASTER, WD .

INTERNATIONAL JOURNAL OF CANCER, 1994, 57 (04) :504-507

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