Synthesis of a novel amino acid based dendrimer

被引：52

作者：

Mulders, SJE ^{[1
]}

Brouwer, AJ ^{[1
]}

vanderMeer, PGJ ^{[1
]}

Liskamp, RMJ ^{[1
]}

机构：

[1] UNIV UTRECHT,UTRECHT INST PHARMACEUT SCI,DEPT MED CHEM,NL-3508 TB UTRECHT,NETHERLANDS

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 04期

关键词：

D O I：

10.1016/S0040-4039(96)02358-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An easy accessible dendrimer monomer 3,5-bis(2-tert-butyloxycarbonyl aminoethoxy) benzoic acid methyl ester 1 was designed. The monomer was converted to both the ''surface'' and ''braching'' monomer in a versatile synthesis of a novel amino acid based dendrimer by the covergent method, using the well established and high-yielding BOP-peptide coupling method. (C) 1997, Elsevier Science Ltd. All rights reserved.

引用

页码：631 / 634

页数：4

共 40 条

[1] BUHLEIER E, 1978, SYNTHESIS-STUTTGART, P155
[2] 1-HYDROXY-7-AZABENZOTRIAZOLE - AN EFFICIENT PEPTIDE COUPLING ADDITIVE
CARPINO, LA
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1993, 115 (10) : 4397 - 4398
[3] CASTRO B, 1975, TETRAHEDRON LETT, V14, P1219
[4] CASTRO B, 1989, Patent No. 8902361
[5] Asymmetric dihydroxylation enables rapid construction of chiral dendrimers based on 1,2-diols
Chang, HT
Chen, CT
Kondo, T
Siuzdak, G
Sharpless, KB
[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1996, 35 (02): : 182 - 186
[6] SYNTHESIS AND CHARACTERIZATION OF OPTICALLY-ACTIVE, HOMOCHIRAL DENDRIMERS
CHOW, HF
FOK, LF
MAK, CC
[J]. TETRAHEDRON LETTERS, 1994, 35 (21) : 3547 - 3550
[7] OXYBENZOTRIAZOLE FREE PEPTIDE COUPLING REAGENTS FOR N-METHYLATED AMINO-ACIDS
COSTE, J
FREROT, E
JOUIN, P
CASTRO, B
[J]. TETRAHEDRON LETTERS, 1991, 32 (17) : 1967 - 1970
[8] Dandliker PJ, 1995, ANGEW CHEM INT EDIT, V34, P2725
[9] DANDLIKER PJ, 1994, ANGEW CHEM INT EDIT, V33, P1739, DOI 10.1002/anie.199417391
[10] De Brabander-van den Berg E.M.M., 1993, ANGEW CHEM INT EDIT, V105, P1370

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