Tuning the coordination number of hydroxypyridonate-based gadolinium complexes: Implications for MRI contrast agents

被引：38

作者：

Pierre, VC

Botta, M

Aime, S

Raymond, KN ^{[1
]}

机构：

[1] Univ Calif Berkeley, Dept Chem, Berkeley, CA 94720 USA

[2] Univ Piemonte Orientale, Dipartimento Sci Ambiente & Vita, I-15100 Alessandria, Italy

[3] Univ Turin, Dipartimento Chim, IFM, I-10125 Turin, Italy

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2006年 / 128卷 / 16期

关键词：

D O I：

10.1021/ja057805x

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Eight-coordinate hydroxypyridinone/terephthalamide GdIII complexes display high relaxivities due to their two inner sphere water molecules. This relaxivity can be further increased by functionalizing the terephthalamide moiety with an amine. A significant hydrogen bonding interaction between the amine and another water molecule close to the GdIII apparently facilitates its coordination on the open site of the metal. The resulting nine-coordinate complex has three inner sphere water molecules, while maintaining high stability and fast ligand exchange rates. Copyright © 2006 American Chemical Society.

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页码：5344 / 5345

页数：2

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