New developments in zinc-catalyzed asymmetric hydrosilylation of ketones with PMHS

被引：89

作者：

Bette, V

Mortreux, A

Savoia, D

Carpentier, JF

机构：

[1] Univ Rennes 1, UMR 6509 CNRS, Inst Chim, F-35042 Rennes, France

[2] Univ Lille 1, UPRESA 8010 CNRS, ENSCL, F-59652 Villeneuve Dascq, France

[3] Univ Bologna, Dipartimento Chim G Ciamician, I-40126 Bologna, Italy

来源：

TETRAHEDRON | 2004年 / 60卷 / 12期

关键词：

asymmetric catalysis; diamines; hydrosilylation; ketones; PMHS; zinc;

D O I：

10.1016/j.tet.2004.01.051

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The influence of structural modifications of the diamine ligand and the ZnR2 precursor in the [ZnR2-diamine]-catalyzed asymmetric hydrosilylation of prochiral ketones with PMHS in aprotic medium is reported. A new diamine ligand giving up to 91% ee in the reduction of acetophenone is described. The scope of this reduction system has been investigated using variously functionalized ketones and some deactivation pathways have been identified. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：2837 / 2842

页数：6

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