Stathmin-like 2, a developmentally-associated neuronal marker, is expressed and modulated during osteogenesis of human mesenchymal stem cells

被引：29

作者：

Chiellini, Chiara ^{[1
]}

Grenningloh, Gabriele ^{[2
]}

Cochet, Olivia ^{[1
]}

Scheideler, Marcel ^{[3
]}

Trajanoski, Zlatko ^{[3
]}

Ailhaud, Gerard ^{[1
]}

Dani, Christian ^{[1
]}

Amri, Ez-Zoubir ^{[1
]}

机构：

[1] Univ Nice Sophia Antipolis, CNRS, IBDC, F-06108 Nice 2, France

[2] Univ Lausanne, Ctr Psychiat Neurosci, Dept Psychiat CHUV, CH-1008 Prilly, Switzerland

[3] Graz Univ Technol, Inst Genom & Bioinformat, A-8010 Graz, Austria

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2008年 / 374卷 / 01期

基金：

奥地利科学基金会;

关键词：

stathmin-like; 2; stem cells; differentiation; osteoblast;

D O I：

10.1016/j.bbrc.2008.06.121

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Stathmin-like 2 (STMN2) protein. a neuronal protein of the stathmin family, has been implicated in the microtubule regulatory network as a crucial element of cytoskeletal regulation. Herein, we describe that STMN2 expression increases at both mRNA and protein levels during osteogenesis of human mesenchymal stem cells derived from adipose tissue (hMADS cells) and bone marrow (hBMS cells), whereas it decreases to undetectable levels during adipogenesis. STMN2 protein is localized in both Golgi and cytosolic compartments. Its expression appears modulated in osteoblasts by nerve growth factor, dexamethasone or RhoA kinase inhibitor Y-27632 which are known effectors of osteogenesis. Thus STMN2 appears a novel marker of osteogenesis and osteoblast per se, that could play a role in the regulation of the adipocyte/osteoblast balance. (C) 2008 Elsevier Inc. All rights reserved.

引用

页码：64 / 68

页数：5

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