Diphenyl 2-pyridylphosphine and di-tert-butyl azodicarboxylate:convenient reagents for the Mitsunobu reaction

被引：67

作者：

Kiankarimi, M ^{[1
]}

Lowe, R ^{[1
]}

McCarthy, JR ^{[1
]}

Whitten, JP ^{[1
]}

机构：

[1] Neurocrine Biosci Inc, Dept Med Chem, San Diego, CA 92121 USA

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 24期

关键词：

Mitsunobu reactions;

D O I：

10.1016/S0040-4039(99)00819-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

New reagents that resolve the problem of separating products from the numerous byproducts in the Mitsunobu reaction have been introduced. Substitution of a basic triarylphosphine and an acid labile azodicarboxylate for triphenylphosphine and diethy azodicarboxylate provide an improved procedure allowing for facile isolation of desired products in good yields and excellent purity. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：4497 / 4500

页数：4

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