Polymer-bound triphenylphosphine as traceless reagent for Mitsunobu reactions in combinatorial chemistry: Synthesis of aryl ethers from phenols and alcohols

被引：76

作者：

Tunoori, AR

Dutta, D

Georg, GI ^{[1
]}

机构：

[1] Univ Kansas, Dept Med Chem, Higuchi Biosci Ctr, Lawrence, KS 66045 USA

[2] Univ Kansas, Higuchi Biosci Ctr, Drug Discovery Program, Lawrence, KS 66045 USA

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 48期

关键词：

D O I：

10.1016/S0040-4039(98)01988-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of aryl ethers from phenols and alcohols using polymer-bound triphenylphosphine and diethyl azodicarboxylate (DEAD) is described. The polymer-bound triphenylphosphines are easily removed by filtration from the reaction products. This method is operationally simple and provides the products with high purity and in good yields. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：8751 / 8754

页数：4

共 15 条

[1] ESTERIFICATION USING A POLYMER-SUPPORTED PHOSPHINE REAGENT [J].