Novel C-ring analogues of 20(S)-camptothecin-Part-2:: Synthesis and in vitro cytotoxicity of 5-C-substituted 20(S)-camptothecin analogues

被引：26

作者：

Subrahmanyam, D ^{[1
]}

Venkateswarlu, A

Rao, KV

Sastry, TVRS

Vandana, G

Kumar, SA

机构：

[1] Dr Reddys Res Fdn, Nat Prod Div, Hyderabad 500050, Andhra Pradesh, India

[2] Dr Reddys Res Fdn, Div Biotechnol, Hyderabad 500050, Andhra Pradesh, India

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 12期

关键词：

D O I：

10.1016/S0960-894X(99)00268-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of 5-C-substituted 20(S)-camptothecin analogues were synthesised and evaluated their in vitro anti-cancer activity. Several of these analogues have showed excellent activity against human tumor cell lines. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：1633 / 1638

页数：6

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