7-silylcamptothecins (silatecans): A new family of camptothecin antitumor agents

被引：63

作者：

Josien, H

Bom, D

Curran, DP ^{[1
]}

Zheng, YH

Chou, TC

机构：

[1] Univ Pittsburgh, Dept Chem, Pittsburgh, PA 15260 USA

[2] Mem Sloan Kettering Canc Ctr, Biochem Pharmacol Lab, New York, NY 10021 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 24期

关键词：

D O I：

10.1016/S0960-894X(97)10181-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis and biological evaluation of about one dozen 7-silylcamptothecin derivatives are described. Most new compounds show potencies comparable to or better than camptothecin itself. The best compound, 11-fluoro-10-amino-7-trimethylsilylcamptothecin, is more than 20 times more potent than camptothecin in cell assays. (C) 1997 Elsevier Science Ltd.

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页码：3189 / 3194

页数：6

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