Tandem radical reactions of isonitriles with 2-pyridonyl and other aryl radicals: Scope and limitations, and a first generation synthesis of (+/-)-camptothecin

被引:100
作者
Curran, DP
Liu, H
Josien, H
Ko, SB
机构
[1] Department of Chemistry, University of Pittsburgh, Pittsburgh
关键词
D O I
10.1016/0040-4020(96)00633-3
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Photolysis of N-propargyl-6-halo-2-pyridones and related aromatic halides in the presence of aryl isonitriles provides tetra- and pentacyclic products in a single step by a sequence of radical addition to the isonitrile followed by two cyclizations. The scope and limitations of the process are described along with a first generation synthesis of racemic camptothecin. Copyright (C) 1996 Elsevier Science Ltd
引用
收藏
页码:11385 / 11404
页数:20
相关论文
共 68 条