ANTITUMOR AGENTS .5. SYNTHESIS AND ANTILEUKEMIC ACTIVITY OF E-RING-MODIFIED (RS)-CAMPTOTHECIN ANALOGS

被引：24

作者：

EJIMA, A

TERASAWA, H

SUGIMORI, M

OHSUKI, S

MATSUMOTO, K

KAWATO, Y

YASUOKA, M

TAGAWA, H

机构：

[1] Exploratory Research Laboratories I, Daiichi Pharmaceutical Co., Ltd., Tokyo 134, 16–13, Kitakasai 1-chome, Edogawa-ku

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 1992年 / 40卷 / 03期

关键词：

CAMPTOTHECIN; AMINOCAMPTOTHECIN; FRIEDLANDER CONDENSATION; ANTITUMOR ACTIVITY;

D O I：

10.1248/cpb.40.683

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Several E-ring-modified analogues of (RS)-camptothecin were synthesis via Friedlander condensation and evaluated for cytotoxicity and antitumor activity against P388 mouse leukemia cells. Among them, (RS)-20-deoxyamino-7-ethyl-10-methoxycamptothecin (25c) was found to be more active than (RS)-camptothecin (1) in the in vivo assay.

引用

页码：683 / 688

页数：6

共 15 条

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