A controlled release of ibuprofen by systematically tailoring the morphology of mesoporous silica materials

被引：160

作者：

Qu, Fengyu

Zhu, Guangshan ^{[1
]}

Lin, Huiming

Zhang, Weiwel

Sun, Jinyu

Li, Shougui

Qiu, Shilun

机构：

[1] Jilin Univ, State Key Lab Inorgan Synth & Preparat Chem, Changchun 130023, Peoples R China

[2] Jiamusi Univ, Chem & Pharmaceut Coll, Jiamusi 154007, Peoples R China

来源：

JOURNAL OF SOLID STATE CHEMISTRY | 2006年 / 179卷 / 07期

基金：

中国国家自然科学基金;

关键词：

mesoporous silica; morphology; ibuprofen; controlled release;

D O I：

10.1016/j.jssc.2006.04.002

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A series of mesoporous silica materials with similar pore sizes, different morphologies and variable pore geometries were prepared systematically. In order to control drug release, ibuprofen was employed as a model drug and the influence of morphology and pore geometry of mesoporous silica on drug release profiles was extensively studied. The mesoporous silica and drug-loaded samples were characterized by X-ray diffraction, Fourier transform IR spectroscopy, N-2 adsorption and desorption, scanning electron microscopy, and transmission electron microscopy. It was found that the drug-loading amount was directly correlated to the Brunauer Emmctt-Teller surface area, pore geometry, and pore volume; while the drug release profiles could be controlled by tailoring the morphologies of mesoporous silica carriers. (C) 2006 Elsevier Inc. All rights reserved.

引用

页码：2027 / 2035

页数：9

共 26 条

[1] Influences of material characteristics on ibuprofen drug loading and release profiles from ordered micro- and mesoporous silica matrices [J].