Genomic structure of human BST-1

被引：29

作者：

Muraoka, O ^{[1
]}

Tanaka, H ^{[1
]}

Itoh, M ^{[1
]}

Ishihara, K ^{[1
]}

Hirano, T ^{[1
]}

机构：

[1] OSAKA UNIV, SCH MED, CTR BIOMED RES, DEPT MOL ONCOL, SUITA, OSAKA 565, JAPAN

来源：

IMMUNOLOGY LETTERS | 1996年 / 54卷 / 01期

关键词：

BST-1; genomic; human; structure;

D O I：

10.1016/S0165-2478(96)02633-8

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

BST-1 is an ectoenzyme expressed on human bone marrow. Stromal cells and myeloid lineage cells, having both ADP-ribosyl cyclase and cyclic ADP-ribose (cADPR) hydrolase activities. In mouse, BST-1 is also expressed on lymphoid progenitors. We isolated chromosomal DNA segments of the human BST-1 gene. The human BST-1 gene consisted of nine exons and eight introns. The length of each exon was very similar to that of the Aplysia ADP-ribosyl cyclase gene. The flanking region of the BST-1 gene contained several potential binding sites for nuclear factors, NF-kappa B, p53, NF-IL6, CREB, PEA3, E2A, C/EBP, AP3, AP2 and SP1 and consensus sequences for gamma-IRE and ISRE like element. Copyright (C) 1996 Elsevier Science B.V.

引用

页码：1 / 4

页数：4

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