Quantitative Analysis of the Fate of Gold Nanocages In Vitro and In Vivo after Uptake by U87-MG Tumor Cells

被引：29

作者：

Cho, Eun Chul ^{[1
]}

Zhang, Yu ^{[1
]}

Cai, Xin ^{[1
]}

Moran, Christine M. ^{[1
]}

Wang, Lihong V. ^{[1
]}

Xia, Younan ^{[1
]}

机构：

[1] Washington Univ, Dept Biomed Engn, St Louis, MO 63130 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 04期

关键词：

biological activity; cell uptake; drug delivery; gold; nanoparticles; CELLULAR UPTAKE; DRUG-DELIVERY; NANOPARTICLES; SURFACE; SIZE; INTERNALIZATION; CYTOTOXICITY; PENETRATION; ADSORPTION; MICROSCOPY;

D O I：

10.1002/anie.201208096

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

Not always equal: When a mother cell that contains Au nanocages divides, the nanoparticles are unequally distributed between the two daughter cells. This unequal distribution of nanoparticles as well as their clearance from the cells (see picture) is quantitatively analyzed both in vitro and in vivo using two-photon microscopy and photoacoustic microscopy, respectively. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：1152 / 1155

页数：4

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