Calorie restriction in primates: Will it work and how will we know?

被引：151

作者：

Roth, GS ^{[1
]}

Ingram, DK ^{[1
]}

Lane, MA ^{[1
]}

机构：

[1] Johns Hopkins Univ, Gerontol Res Ctr, NIH, NIA,Bayview Med Ctr, Baltimore, MD 21224 USA

来源：

JOURNAL OF THE AMERICAN GERIATRICS SOCIETY | 1999年 / 47卷 / 07期

关键词：

aging; caloric restriction; humans; primates;

D O I：

10.1111/j.1532-5415.1999.tb03851.x

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Dietary caloric restriction is the most robust and reproducible means of slowing aging and extending lifespan and healthspan in short-lived mammals and lower organisms. Numerous aspects of this paradigm have been investigated in laboratories around the world since its inception more than 60 years ago. However, two questions about calorie restriction remain unanswered to this day: (1) By what mechanism does it work? and (2) Will it work in humans? This review will focus on the latter with particular emphasis on evaluation criteria, current studies in primate models,available data, and plans for actual human caloric restriction interventions.

引用

页码：896 / 903

页数：8