Systems pharmacogenomics in yeast

被引：1

作者：

Cahan, P ^{[1
]}

Marsh, S ^{[1
]}

McLeod, HL ^{[1
]}

机构：

[1] Washington Univ, Sch Med, Div Oncol, Dept Med,Computat Biol Program, St Louis, MO 63110 USA

来源：

PHARMACOGENOMICS | 2006年 / 7卷 / 02期

关键词：

chemotherapy resistance; pharmacogenomics; systems biology;

D O I：

10.2217/14622416.7.2.255

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Despite intense study, the mechanistic and therapeutic differences in cellular responses to DNA-damaging agents are not fully understood. In order to expand knowledge of DNA damage, the authors of this study assayed the effects of 12 anticancer agents on the complete pool of approximately 4700 homozygous deletion strains of Saccharomyces cerevisiae. The screens identified genes in well-characterized DNA, in addition to genes whose role in DNA-damage-response pathways had not previously been established.

引用

页码：255 / 259

页数：5

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