Novel preparation of (-)-4-hydroxycyclohex-2-enone: reaction of 4-hydroxycyclohex-2-enone and 4-hydroxycyclopent-2-enone with some thiols

被引：15

作者：

Bickley, JF

Evans, P

Meek, A

Morgan, BS

Roberts, SM

机构：

[1] Univ Manchester, CoEBio3, Manchester M60 1QD, Lancs, England

[2] Univ Dublin Trinity Coll, Dept Chem, Dublin 2, Ireland

[3] Univ Liverpool, Dept Chem, Liverpool L69 7ZD, Merseyside, England

来源：

TETRAHEDRON-ASYMMETRY | 2006年 / 17卷 / 03期

关键词：

D O I：

10.1016/j.tetasy.2006.01.002

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A new route to (R)-4-hydroxycyclohex-2-enone from cyclohexanedione monoketal (27% yield) commences with reaction of the ketal with nitrosobenzene catalysed by L-proline. 4-Hydroxycyclohex-2-enone and 4-hydroxycyclopent-2-enone react with thiols to afford the corresponding syn-disubstituted cycloalkanones. (c) 2006 Published by Elsevier Ltd.

引用

收藏

页码：355 / 362

页数：8

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