Synthesis of 4-azacyclopent-2-enones and 5,5-dialkyl-4-azacyclopent-2-enones

被引：38

作者：

Dauvergne, J

Happe, AM

Jadhav, V

Justice, D

Matos, MC

McCormack, PJ

Pitts, MR

Roberts, SM

Singh, SK

Snape, TJ

Whittall, J

机构：

[1] Univ Liverpool, Charterhouse Therapeut Ltd, Liverpool L69 7ZD, Merseyside, England

[2] Stylacats Ltd, Dev Labs, Ellesmere Port, Cheshire, England

[3] Univ Liverpool, Stylacats Ltd, Res Labs, Liverpool L69 7ZD, Merseyside, England

来源：

TETRAHEDRON | 2004年 / 60卷 / 11期

关键词：

4-aza-cyclopentenones; 4-aza-cyclopent-2-en-1-ols; asymmetric synthesis of aminocyclopentenols; lipase resolution;

D O I：

10.1016/j.tet.2004.01.046

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Three different methods are reported for the preparation of 4-azacyclo-2-enones 1, two of which allow the preparation of the compounds in optically active form. In addition, a facile route to 4-aza-5,5-dimethyleyclopent-2-enones 2 is disclosed. (C) 2004 Elsevier Ltd. All rights reserved.

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收藏

页码：2559 / 2567

页数：9

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