Critical roles for c-Myb in hematopoietic progenitor cells

被引：106

作者：

Greig, Kylie T. ^{[1
,2
]}

Carotta, Sebastian ^{[1
]}

Nutt, Stephen L. ^{[1
]}

机构：

[1] Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, Australia

[2] Univ Melbourne, Dept Med Biol, Parkville, Vic 3052, Australia

来源：

SEMINARS IN IMMUNOLOGY | 2008年 / 20卷 / 04期

关键词：

c-Myb; transcription factor; hematopoiesis; p300; differentiation;

D O I：

10.1016/j.smim.2008.05.003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

While it has long been known that the transcription factor c-Myb is an essential regulator of hematopoiesis, its precise molecular targets have remained elusive. Cell line studies suggest that c-Myb promotes proliferation and at the same time inhibits differentiation, however the early lethality of c-Myb deficient embryos precluded analysis of its role in adult hematopoiesis. Here we review insights derived from recently developed mouse models of c-Myb deficiency that are viable as adults. These studies reveal a complex array of functions for c-Myb in multiple hematopoietic cell types that will redefine our understanding of this crucial transcription factor. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：247 / 256

页数：10

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